A Synthetic Biology Approach For a Vaccine Platform Against Known and Newly Emerging 1 Serotypes of Bluetongue Virus 2 3 Sandro

A Synthetic Biology Approach For a Vaccine Platform Against Known and Newly Emerging 1 Serotypes of Bluetongue

A Synthetic Biology Approach for a Vaccine Platform against Known and Newly Emerging Serotypes of Bluetongue Virus

UNLABELLED Bluetongue is one of the major infectious diseases of ruminants and is caused by bluetongue virus (BTV), an arbovirus existing in nature in at least 26 distinct serotypes. Here, we describe the development of a vaccine platform for BTV. The advent of synthetic biology approaches and the development of reverse genetics systems has allowed the rapid and reliable design and production o...

Evaluation of cross-protection of bluetongue virus serotype 4 with other serotypes in sheep.

Bluetongue (BT) is a non-contagious disease of sheep and other domestic and wild ruminants caused by the bluetongue virus (BTV). Currently 26 serotypes of the virus have been identified. In South Africa, 22 serotypes have been identified and BT is controlled mainly by annual vaccinations using a freeze-dried live attenuated polyvalent BTV vaccine. The vaccine is constituted of 15 BTV serotypes ...

Sero-prevalence of bluetongue disease in sheep in west and northwest provinces of Iran

The objective of this study was to describe the seroprevalence rates of bluetongue virus (BTV) in sheep in west and northwest provinces of Iran. Bluetongue virus, an economically important orbivirus of the Reoviridae family, causes a hemorrhagic disease mainly in sheep and occasionally in cattle and some species of deer. Bluetongue virus is transmitted between its mammalian hosts by ce...

Characterization of Protection Afforded by a Bivalent Virus-Like Particle Vaccine against Bluetongue Virus Serotypes 1 and 4 in Sheep

BACKGROUND Bluetongue virus (BTV) is an economically important, arthropod borne, emerging pathogen in Europe, causing disease mainly in sheep and cattle. Routine vaccination for bluetongue would require the ability to distinguish between vaccinated and infected individuals (DIVA). Current vaccines are effective but are not DIVA. Virus-like particles (VLPs) are highly immunogenic structural mimi...